Abstract
Thymidylate synthase is required for the synthesis of DNA. Folic acid can be synthesized by bacteria, but not animals. Drugs that inhibit H2 folate reductase, or thymidylate synthase, are effective anticancer agents. The megaloblastic anemia associated with vitamin B12 deficiency can be partially alleviated by extra folate in the diet. Serine becomes a methyl donor in dTMP, and thus contributes positively to DNA formation. Thioredoxin and NADPH aid in the conversion of NDPs to their corresponding dNDPs for DNA synthesis. Antimetabolites that inhibit ribonucleoside diphosphate reductase (RDR) reduce the number of dNTPs available for DNA synthesis.
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