Abstract
This chapter describes transporter blockers, enzyme inhibitors and metabolic modifiers and their potential in pH gradient reversal. Some of this drugs act only on the pH, while others such as metabolic modifiers, act on the pH by inhibiting either the glycolytic or the oxidative pathway. One of these drugs, 3-bromopyruvate, is currently undergoing intensive research and will probably enter clinical practice in the near future. Acetazolamide, a long known FDA-approved diuretic is one of the best companions of pH reversal treatments, because membrane carbonic anhydrases are key figures in the pH alteration in cancers. A large group of drugs, whose exact mechanisms of action are only partially known, are also included in this chapter. As explained in the two previous chapters, none of these drugs are stand-alone therapies.
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