Abstract
The prefrontal cortex (PFC) is a brain region that modulates higher-order (executive) cognitive process. The functional organization of the neural networks of the PFC has increasingly been implicated as being disrupted by alcohol abuse. It appears that deficits in the executive function of the PFC may relate, at least in part, to the alterations in synchronous organization of both localized and globally distributed cell assemblies into a functional integrated network. It is therefore not surprising that many of the behaviors that depend upon optimal activity of the PFC are also impacted by alcohol dependence and abuse. Additional evidence has also suggested a negative interaction of stress and chronic alcohol on PFC function and associated behaviors. Finally, the adolescent PFC appears to be especially vulnerable to alcohol abuse that can result in alterations in the developmentally regulated synaptic refinement and maturation of executive functions.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
