Abstract
Aging results in structural deteriorations and functional decline of the heart and is a major risk factor for cardiovascular disease, the leading cause of death in the United States and other Western populations. As the elderly population is continuously growing, the prevalence and economic burden of age-related cardiovascular disabilities continue to rise. To address the clinical burden of cardiac aging, researchers have made significant progress in understanding the biology of the aging heart and are beginning to develop strategies to prevent or treat age-related cardiac dysfunction. This chapter provides an overview of cardiac aging in humans and animal models, discusses how different molecular mechanisms contribute to the pathogenesis of cardiac aging, and introduces several interventions that have shown promise in treating age-related cardiac dysfunction.
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