Abstract

Vitamin B6 activity is metabolically active in the form of pyridoxal phosphate, an essential cofactor for more than 140 enzymes most of which are involved in the metabolism of amino acids, with functional roles in growth, immune function, and other aspects of metabolism. Vitamin B6 is widely distributed in foods, including meats, whole grain products, and vegetables. It is water soluble and it is absorbed by passive diffusion after which ingested forms are converted to any of several vitamers (pyridoxamine, pyridoxine, and pyridoxal) and pyridoxal phosphate. Vitamin B6 contributes to single-carbon metabolism, niacin synthesis, and gluconeogenesis. Vitamin B6 deficiency is rare in humans; it presents as muscular weakness, nervous disorders, and impaired cell-mediated immunity.

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