Abstract

Biomaterial surface properties are critical to the successful integration of tissue engineering scaffolds. Biological interactions which occur at the biomaterial interface are influenced by a broad array of factors, including surface characteristics such as chemistry, charge, wettability, and topography. Biomaterial surface modification strategies for prevention of non-specific protein adsorption, promotion of specific cellular adhesion, and surface-based delivery of bioactive molecules have thus become an exciting area of investigation. Here, we review the wide variety of biomaterial surface functionalization techniques employed, with a particular focus on presenting methods that are applicable to polymeric materials and bone tissue engineering applications.

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