Abstract
Among the different functions of astrocytes, their contribution to the neuroinflammatory response is a relevant one. This chapter reviews the inflammatory response in the central nervous system and the causes and effects of astroglial activation, paying special attention to the resulting neurological damage and how this facilitates the progression of certain neurodegenerative diseases. Based on this, it is also discussed how those agents able to control the toxic actions of astrocytes are of great interest from a therapeutic point of view. Noradrenaline is one of these agents. Besides its role as a neurotransmitter, it can also regulate other actions within the central nervous system. The noradrenaline deficit in diverse neurodegenerative diseases is discussed here, as well as the mechanisms through which noradrenaline can prevent those transformations of astrocytes that lead to the damage and loss of healthy neurons.
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