Chapter 14 - Interactions Between Toxoplasma Effectors and Host Immune Responses

Abstract

As an intracellular parasite, Toxoplasma gondii must avoid a variety of host defences including the host immune response. Recent studies have demonstrated that T. gondii extensively remodels its host altering host metabolism and gene expression. These events are mediated by parasite products that are secreted into the host cell during and after invasion. This chapter discusses the identification and mechanism of action of the rhoptry and dense granule proteins that alter host cell signalling and immune response.