Abstract
There is growing evidence that implicates the epigenome in the development of bone and joint disorders. The complexity and dynamic nature of epigenetic regulations confound the investigation of these disorders. We will review current evidence that connects epigenetics to the development of autoimmune and musculoskeletal diseases. The pathogenesis of these disorders is likely to be related to modifications to epigenetics regulation by environmental signals in individuals with a certain genetic makeup. The epigenome is an attractive therapeutic target; however, successful epigenetic-based treatment will depend on a greater understanding of the molecular mechanisms controlling the epigenome and its alteration in rheumatic and bone disorders.
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