Abstract
PTEN-induced kinase1 (PINK1) is a Ser/Thr kinase localized in mitochondria. It is well known for its ubiquitous nature and its role in many human pathologies, including diabetes, cancer, inflammation, and cardiopulmonary dysfunctions. Various studies have revealed the crucial role of PINK1 in the mitochondrial quality control pathway, which is essential for identifying damaged mitochondria and leads to their elimination by mitophagy. PINK1 was first identified as one of the central genes involved in Parkinson's disease. PINK1 works in concert with Parkin, an E3 ubiquitin ligase, to tag a mitochondrion for proteolytic degradation. As more research is being done to elucidate the involvement of the mitochondria in diseases, PINK1’s role in the manifestation of the disease is also being unveiled. This chapter introduces and summarizes the structure and physiological role of PINK1 and its role in various mitochondrial-related diseases, including Parkinson's disease (PD), diabetes, cancer, etc.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
