Abstract
Marrow-ablative chemotherapy with autologous hematopoietic progenitor cell rescue has been evaluated in the treatment of children, adolescents, and young adults with brain tumors, in whom conventional therapy is either considered too toxic (e.g., radiotherapy in infants) or has proven ineffective (e.g., recurrent or progressive malignant tumors). The success of this approach depends on tumor type and histology, extent of disease and surgical resection, and response to prior chemotherapy. In this chapter, we review results of marrow-ablative chemotherapy with autologous hematopoietic progenitor cell rescue as well as allogeneic transplantation in brain tumors of different histologies.
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