Abstract
It has been increasingly evident in recent years that the rapid change from glass containers to the almost universal use of plastics as infusion containers as well as for the administration systems has generated some unforeseen adverse effects. Polymer compounds and other materials (medicinal plastics) are widely used in plastics in pharmaceutical packaging, syringes, filters, and intravenous administration equipment. Plastic materials used in medicine and pharmacy may interact with medicinal substances principally by absorption, adsorption, and permeation. Of these mechanisms, absorption into a plastics material is probably the most important mechanism underlying interactions. No drug should be added to any intravenous fluid unless it is known that the drug is stable in the fluid, and that it does not interact with the materials of the container or administration equipment. Most reports of interactions between drugs and plastics materials have originated from studies to determine the stability of drugs in plastics containers, syringes, plastics infusion bags, and filters.
Published Version
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