Abstract
Alzheimer's disease (AD) is the most common form of dementia. Despite extensive efforts using traditional drug discovery platforms, so far none have proven successful. This chapter provides an overview of recent advances in three-dimensional (3D) modeling of AD using human neural cells and their implications for drug discovery. Mechanistic aspects of different types of 3D AD human cellular models, including 3D brain organoid models and our engineered 3D culture models, will be explained and their potential impacts on AD drug discovery will be discussed. Our ongoing efforts to develop a valid high-throughput 3D AD culture platform will be also described. Finally, the perspective and challenges of accelerating AD drug discovery using novel human 3D culture models of AD will be discussed.
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