Abstract
In response to hemorrhage, circulating platelets adhere to exposed subendothelial tissues and then recruit additional platelets into aggregates that function as procoagulant surfaces. In response to infl ammatory stimuli, circulating leukocytes roll and then arrest on endothelial cells, and fi nally migrate into the surrounding tissues where they combat pathogens and repair tissue injury. These traditionally separate cellular adhesive contributions to coagulation and infl ammation have become progressively understood to be linked. We now know that leukocytes roll and then arrest on activated platelets and that platelets roll on activated endothelial cells. Cell adhesion molecules that were fi rst thought to contribute uniquely to either coagulation or infl ammation are now known to contribute to both responses. This chapter focuses on multicellular adhesive interactions in the vasculature, with particular attention to the dual functions in coagulation and infl ammation of the adhesion molecules P-selectin (CD62P), P-selectin glycoprotein ligand 1 (PSGL-1), and glycoprotein (GP) Ibα. (GPIbα is also discussed in Chapter 7. Inhibition of platelet function by the endothelium is discussed in Chapter 13.)
Published Version
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