Abstract
The functional anatomy and physiology of muscle, bone, and joints provide a basis for understanding the spontaneous and induced lesions that occur in these tissues in non-human primates (NHPs) commonly utilized in toxicology studies (cynomolgus macaques, rhesus macaques, and marmosets). To be able to interpret induced changes when evaluating the musculoskeletal system in toxicology studies, it is important to have a good understanding of gross and microscopic spontaneous lesions within the context of these studies. Spontaneous and induced lesions in these tissues include changes that are degenerative, congenital, inflammatory, proliferative, and neoplastic, all of which are discussed in the chapter, with associated illustrative images.
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