Abstract
Microbes play a role as the second largest biomass on Earth. Bacterial metabolites are the intermediate products of chemical process synthesized in enzymatic reactions, usually as small molecules. The unprecedented value of bacterial metabolites paved the way for the pharmaceuticals industry, agronomy, and clinical products. Bacterial metabolites linked to systemic diseases and peripheral diseases are comprised of neurological and metabolic disorders, chronic gastrointestinal disorders, and inflammatory bowel diseases. The molecular interactions between biological targets and bacterial metabolites have been standardized over thousands of years of human evolution and lead to the discovery of chemical structures and application of drugs. In recent decades, high-throughput applications of functional genomics, transcriptomics, proteomics, spatial metabolomics, and metagenomics has been conceived as an intensive foundation of the underpinning biosynthetic principle of bacterial metabolites. This chapter discusses the different scenarios of valuable bacterial metabolites, such as the biological industry and its various purposes, and brings to light the recent progress made in targeted “omics” technologies for nutrition, healthcare, and agricultural productions.
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