Abstract
Natural products are promising chemicals because of their structural diversity and bioactivities, which have broad applications in the pharmaceutical, food, cosmetics, and flavor industries. Current manufacturing methods for these value-added products mainly rely on plant extraction and chemical synthesis, which are associated with unsustainability and severe environmental problems. Metabolic engineering has been considered as a powerful tool for sustainable and environmental-friendly production of many natural products. In this section, the endeavor in metabolic engineering of microorganisms to produce the three main categories of plant secondary metabolites, namely polyphenols, alkaloids, terpenoids, and high-value oleo-chemicals is reviewed. The most emphasis is placed on developing optimization strategies and pathway construction to biosynthesize these value-added products and to improve their titer and yield. Furthermore, the current challenges and future perspectives on successful strain development for large-scale production in an industrial level are discussed.
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