Abstract
Continuous manufacturing (CM) is evolving as a preferred platform for pharmaceutical products involving solid dosages forms. One advantage of CM, among many, is that the product quality can be controlled in real time and thereby it opens the possibilities of achieving Quality by Control and real-time release paradigms. However, there are many challenges associated with design and implementation of an efficient control system into a pharmaceutical manufacturing plant. Identification of the right control strategies (e.g., feedforward, feedback, or a combination of both) as well as the right control algorithms (i.e., PID [proportional integral derivative], MPC [model predictive control], or hybrid MPC-PID) is often a tough decision that needs to be made prior to implementation of an integrated control system into the manufacturing plant. In this book chapter, the design and implementation of an efficient control system for direct compaction continuous tablet manufacturing process has been described. Upon a relatively simple level of standardization, the control system can be designed to be modular in nature, in that it can be easily transferred to any other control platform and pharmaceutical manufacturing plant.
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