Abstract
The focus of this chapter is on the future of preclinical abuse liability assessment with an emphasis on new directions for future evaluations. The growth of the rodent comparator compound database for different clinical indications will impact the industry's scientific tools for designing studies to meet the expectations of regulatory agencies. The development of future models for preclinical assessment and approaches for early compound screening to support portfolio decision making are considered as future areas for growth. Problems related to the testing of compounds with poor solubility and nontraditional parameters are discussed. Continued involvement in regulatory discussions and opportunities to impact future guidelines are seen as critical future activities.
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