Abstract
Publisher Summary This chapter highlights supercritical fluid chromatography (SFC). A supercritical fluid chromatograph is a hybrid instrument assembled from the gas chromatography (GC) and liquid chromatography (LC) components. Mobile phase, in the form of a liquid or pressurized gas, is supplied to the LC pump where the pressure of the fluid is raised above its critical pressure. Samples are introduced into the fluid stream through an LC injection valve and separated on a column placed in a GC oven thermostated above the critical temperature of the mobile phase. An SFC pumping system provides a stable pulseless flow over the operating pressure range (typically 70–400 bar). The role of the oven in SFC is to raise and maintain the temperature of the mobile phase, in a controlled and repeatable manner, above its critical temperature. One of the major attractions of SFC is its ability to mix and match detectors. Most GC and LC detectors can be used with little or no modification on packed- and capillary-column systems.
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