Abstract
Etiology and pathogenesis of pouchitis are likely multifactorial and of multipathway. Clinically, pouchitis represents a spectrum of disease processes with heterogeneous risk factors, clinical features, disease courses, and prognoses. In addition to genetic factors and microbiota, environmental and immunological factors, ischemia/hypoxia, and metabolic factors may contribute to the development of acute pouchitis and/or chronic pouchitis, to a different degree. The stratification of etiopathogenetic pathways will help diagnosis, classification, and management of various forms of pouchitis.
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