Abstract
The characteristics in production and action of Nitric oxide (NO) are similar in cerebral vasodilator nerves and endothelial cells. A study demonstrated that antiserum raised against nitric oxide synthase purified from the rat cerebellum is effective in staining the enzyme in the perivascular nerves and endothelial cells. Ca2+ introduced from the external fluid using Ca2+ channels of a non-L-type is a prerequisite for activating the enzyme and synthesizing NO in these tissues. There is some evidence that Ca2+ liberated from intracellularly stored sites is also available for the synthesis of NO in the endothelial cells. The presence of perivascular nerves containing NOS immunoreactivity in large cerebral arteries of the rat brain is demonstrated. Acetylcholine liberated from cholinergic nerves by electrical stimulation is expected to act on muscarinic receptors on nitroxidergic nerve terminals, resulting in a suppression of the synthesis and release of NO. The effectiveness of ganglionic blocking agents appears to be the only way to determine the involvement of neurogenic NO.
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