Abstract
This chapter addresses approaches to improve DNA sensitivity and efforts made to strengthen reliability with low-level DNA testing. The capability of obtaining a useful DNA profile is only limited by the ability of the forensic investigator to find and collect the appropriate evidence. A DNA profile is obtained from fingerprint residues due to cells that are left on the objects that are touched. DNA technology permits the handles of tools used in crimes, such as knives or guns, to be effectively evaluated and used to link a perpetrator to his/her crime. If a laboratory chooses to perform low-level DNA analysis with enhanced detection methods, interpretation guidelines need to reflect the potential artifacts of this high sensitivity environment. When working with low amounts of DNA template, success rates are often poor. Dedicated “clean” facilities and extreme care are required to avoid or at least limit contamination.
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