Abstract
This chapter presents a two-compartment population model of digoxin in which the clinical effect of the drug correlates best with computed concentrations in the peripheral nonserum compartment rather than the serum concentrations. The model is used to illustrate the development of dosage regimens to achieve target goals in the peripheral rather than the serum concentration compartment. Various degrees of renal function are examined. The ability of digoxin to convert patients with atrial fibrillation or atrial flutter to sinus rhythm, guided by this model as implemented in the BestDose clinical software, is then discussed, along with the relationship between digitalis and potassium, with an illustration of the situation in the case of a very interesting patient.
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