Abstract
Oxygen transport occurs in micro vessels of a wide range of diameters in the human circulation. As a result, there are three distinct flow regimes with different mechanisms of transport. The artificial capillary system gives the unique capability to simulate oxygen uptake and release in vitro in experiments in which all flow, geometric, and transport parameters are controlled and are known accurately. The good agreement between the experimental and mathematical results tends to validate both the experimental methodology and the mathematical model. The results confirm that hemoglobin solutions are much more efficient than red cell suspensions of the same hemoglobin content in oxygen transport over a wide range of vessel diameters. Replacement of even a small fraction of the erythrocytes with extracellular hemoglobin-based oxygen carrier yields substantial enhancement in oxygen transport. Substantially more research is needed on both theoretical and experimental simulation of oxygen transport in both intermediate regime and true capillary regime.
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