Abstract
Publisher Summary This chapter explores comparison of novel stationary phases. It discusses three types of stationary phases—namely, (1) monomeric octadecyl silica (ODs), (2) other silica based stationary phases, and (3) stationary phases based on other solid supports. Different stationary phases have been developed to increase both the types of chemical and physical interactions between the stationary phase and the solutes and the range of permissible modifications of the other variables. The development of new stationary phases can improve existing separations, allow separations that are not currently possible, and increase column durability. The ideal high-performance liquid chromatography (HPLC) column would completely separate any mixture and last indefinitely. A number of spectroscopic, thermal, elemental analysis, and chromatographic methods have been used to characterize stationary phases. Spectroscopic techniques used to provide information in the study of stationary phases and solid supports include infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and electron spectroscopy for chemical analysis (ESCA). Sampling is often performed in the solid phase because stationary phases are bonded to solid, not easily soluble, supports, and crushing the solids would destroy the pore structure and therefore positioning of the stationary phase on the support.
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