Abstract
This chapter is dedicated to the continuous solid support-free liquid–liquid chromatographic process called sequential centrifugal partition chromatography (sCPC). It starts with a short introduction to the fundamentals and specifics of solid support-free liquid–liquid chromatography. It then shows the usefulness of using a predictive thermodynamic method (conductor-like screening model for real solvents) for screening and selection of biphasic solvent systems (i.e., the mobile and stationary phase). By the end of the chapter the principle of the sCPC, a shortcut method for selection of unit operating parameters, and a mathematical model for the simulation of an sCPC unit operation are presented. Last, the presented methods and concepts are demonstrated with an example that includes the design of an sCPC separation of a binary mixture of components with very similar molecular structure.
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