Chapter 10 - Role of cellular oxidative stress in dementia

Abstract

Oxidative stress is well recognized as an important pathological component in many conditions that involve neuronal degeneration and dementia. In this chapter, we summarize experimental data from the literature on the role of oxidative stress in common forms of dementia including Alzheimer's and Parkinson's diseases and vascular and frontotemporal dementias as well as less common pathologies presenting with dementia such as Huntington's disease, the spongiform encephalopathies, and the rare dementia familial encephalopathy with neuroserpin inclusion bodies.