Abstract
The utilization of different carbon sources by platform microbial strains is important for the development of efficient biorefineries. Microbes have their native carbon substrate utilization pattern reflecting evolutionary history. Hence, alteration to confer the ability to utilize nonnative carbon sources or improve inherent carbon metabolisms is necessary to produce desired products at a high yield with suppression of byproduct formation, and thus to decrease the production cost. This is also required for simultaneous or coutilization of different carbon sources by suppressing carbon catabolic repression. This chapter summarizes the various metabolic engineering approaches that have been successfully applied to improve the utilization of various sugars in industrially relevant microbial hosts. In addition, this chapter attempts to demonstrate the potential of these engineered microbes to produce various value-added chemicals.
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