Abstract
Protein methylation plays diverse roles in regulating cellular functions in an epigenetic manner. This dysregulation has been implicated in various diseases. The human genome encodes around 70 protein methyltransferases. PMTs are distinct on the basis of their substrate preference and product specificity. Dissecting methylome in a context-specific manner is a key step toward elucidating biological and pathogenic roles of PMTs. Although it becomes common to characterize individual protein methylation events, it is still challenging to profile methylome with conventional tools. Here the current methods for methylome profiling are reviewed. These methods are further dissected for methylome labeling, methylome enrichment, and sample processing and detection. Representative examples will focus on how their combination facilitates methylome profiling. The limitations of each technology will be also discussed in the context of future needs.
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