Abstract
Water+propylene glycol/sucrose myristate/oil+ethanol microemulsions antimicrobial activity has been examined against the bacterial strains Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative). The oils were R (+)-limonene, isopropyl myristate and caprylic-capric triglyceride. The mixing ratios of (water/propylene glycol) and that of (oil/ethanol) equal twofold and unity. The antimicrobial activity against E. coli is higher in the R (+)-limonene and isopropyl myristate–based microemulsions while the caprylic-capric triglyceride–based microemulsion antimicrobial activity is higher against S. aureus. The activation energy of conductive flow and the free energy of solubilization variations as a function of aqueous phase contents indicate the occurrence of water-in-oil to bicontinuous to oil-in-water structural transitions. The variation in the antimicrobial activity of the formulated microemulsions against both bacterial strains as a function of aqueous phase contents resembles the variations in the activation energy of conductive flow and the free energy of solubilization. This resemblance indicates that the antimicrobial activity of the formulated microemulsions is structurally dependent.
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