Abstract
Advances in methods for sequencing, characterizing, and profiling human genomes have provided a wealth of opportunities for understanding the genetic basis of neuropsychiatric disorders. Alongside the sequencing of the human genome, large-scale efforts have mapped DNA variation in healthy populations, identified variants associated with numerous neuropsychiatric disorders, revealed complex machinery that regulates DNA and protein synthesis, and cataloged the genes expressed in various tissues and throughout development. Intricate knowledge of these genomic advances will help scientists make further progress in research and clinicians to apply these resources and methods to patient populations. This chapter will build a foundation of knowledge for the interpretation of genomics research, application of genomics methods, and creation of genome-guided medicine.
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