Chapter 1 - Personalized Diet and Lifestyle Interventions on Lipids and Lipoproteins

Abstract

Disturbed metabolism of lipid and lipoprotein is a major risk factor for cardiovascular diseases and other metabolic disorders. Circulating lipid profiles are heritable and meanwhile modifiable, mainly by diet habit and lifestyle. Genetic research has identified more than 150 common variants associated with lipid traits; and compelling evidence has shown that diet/lifestyle interventions might affect circulating lipid profiles in humans. Emerging data from observational studies and randomized clinical trials have further shown that dietary and lifestyle factors might modify the genetic factors in determining lipid levels. In addition, the emerging “-omics” research, especially lipidomics, provides potentials to reveal novel and systematic insights into the molecular mechanisms underlying genetic effects, diet/lifestyle influence, and gene–diet/lifestyle interactions. Studies in these research areas hold promise to inform future personalized diet and lifestyle interventions based on genetic background, and eventually to improve lipid profiles and mitigate related disorders.