Abstract
Biochemistry has changed again. Research into the human genome has now been complemented by investigations of the transcriptome, the proteome, and the metabolome and an enormous expansion of knowledge about cellular signaling systems. This has provided new insights into the pathogenesis of cancer and has enabled new therapies for a range of diseases. When we look at metabolism, in addition to the strings of chemical reactions, we now consider the cascades of signaling molecules that control these reactions. We also better understand the links between metabolism and nutrition- and lifestyle-dependent diseases, such as obesity, diabetes, atherosclerosis, and cardiovascular disease. The progress in neurochemistry begins to allow a better grasp of the science underpinning mental health.
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