Abstract
In this chapter, we introduce the basic concepts of macrophages. At first, you will learn the immunological roles of macrophages. Macrophages are the important immune effector cells in both innate and adaptive immunity. They have a unique property called “phagocytosis” removing invasive extracellular pathogens and preventing pathogen infiltration. They can promote inflammation in innate immune response and activate acquired immunity by delivering the antigen they get. Second, you will see macrophages as very plastic cells that play a variety of roles depending on their location and environmental stimuli. They are involved in several homeostasis controls, including wound healing, development, metabolism, and cancer growth. Third, we will explore the origin and polarization of macrophages. They are originated from hematopoietic stem cell and be activated by various signals and polarized into M1/M2 macrophages.
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