Abstract
This chapter presents the introduction and overview of the empty nose syndrome (ENS), highlighting subjects we will consider in detail with corresponding citations from the literature (included in the broad bibliography of 376 references), besides providing complete commentary regarding the fundamental features of ENS along with a review of pertinent nasal physiology, a comprehensive differential diagnosis and an analysis of the various medical, surgical, and psychological treatment options for these desperately distraught patients, some of whom have committed suicide because of their horrific torment. ENS was initially recognized and formally presented to the profession by the Mayo Clinic team in 1994. With over a quarter of a century experience treating hundreds of patients devastated by ENS, we reexamined the existing thinking concerning the etiology, differential diagnosis, diagnosis, treatment, and ultimately preventing this crippling disorder.
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