Abstract
This chapter outlines the agents used to treat peptic ulceration and other gastrointestinal diseases, drugs affecting gastrointestinal motility, and drugs used to treat inflammatory bowel disease. Peptic ulceration and probably stomach cancer are causally related to Helicobacter pylori infection of the gastric and duodenal mucosa. The agents used to treat such diseases are proton pump inhibitors such as omeprazole, lansoprazole, pantoprazole. Both omeprazole and lansoprazole inhibit gastric acid production by blocking the hydrogen–potassium adenosine triphosphate system (the “proton pump”). They are used in the treatment of gastric and duodenal ulcers and for erosive and reflux oesophagitis. Omeprazole is the drug of choice to be used with combined antibiotic therapy. Cisapride is described as a gastrointestinal prokinetic agent, which stimulates lower oesophageal, gastric, small intestinal, and colonic motility, and is used in the treatment of dyspepsia, gastrointestinal reflux, and impaired gastric motility. The drugs used to treat inflammatory diseases are corticosteroids and aminosalicylates. This chapter further stresses on agents used to treat gastrointestinal diseases, their side-effects, recorded interaction, and extent of clinical use.
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