Abstract
Publisher Summary Cisplatin (cis-diamminedichloroplatinum II) is one of the group of platinum coordination complexes, which possess antibiotic activity. Cisplatin causes the inhibition of growth of Escherichia coli and transforms the bacteria into long filamentous structures. Cisplatin has a major role in the chemotherapy of several human malignancies. It is a water-soluble square planar coordination complex containing a central platinum atom surrounded by two chloride atoms and two ammonia moieties. The antitumor activity of the complex is much greater when the chloride and ammonia moieties are in the cis position compared to the trans position. As a prime mechanism of the inhibition of tumor growth by cisplatin appears to be the inhibition of DNA synthesis, it has been suggested that the cis configuration of cisplatin favors the formation of intrastrand crosslinks in DNA. Studies have suggested that the intrastrand crosslinks are formed through the N-7 position of adjacent guanine bases, resulting in the local denaturation of the DNA double helix.
Published Version
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