Abstract
This paper examines the influence of chronic alcoholic intoxication on the qualitative and quantitative composition of the intestinal microbiota in patients with syndrome of alcohol dependence. The authors describe chronic alcoholic intoxication, accompanied by significant violations of homeostasis, which is manifested by changes in protein, carbohydrate, lipid, and mineral metabolism. The authors examine the role of alcohol as one of the main factors that affect dysbiotic shifts in the normal microbiota of human intestines. The paper presents the results of the comparison found earlier in the course of experimental work, significant changes of the intestinal microbiota of rats subjected to chronic alcoholism and clinical results of the study of the microbial landscape in patients with syndrome of alcohol dependence. The authors established that under the influence of alcohol there is a statistically significant reduction in saccharolytic microbiota. The obtained data are a part of a clinic-experimental study of changes in the state of resistance of the organism exposed to the chronic effects of alcohol and can serve as a basis for further study of the intestinal microbiota changes, which is an important component of a personalized approach to the definition of tactics of treatment and rehabilitation of people with the syndrome of alcohol dependence.
Published Version
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