Abstract
Close correlation of Estradiol (E2) concentration and SHBG concentration in serum under the condition of Controlled Ovarian Hyperstimulation (COH) were investigated. E2 and SHBG coordinate each other but their secretion pattern was different. Serum E2 started to increase from D -4, became peak at D +1 then decreased rapidly next 2 days. Serum SHBG started to increase from D -1, reached peak at D +3 then kept high level during luteal phase. Different situations of these hormones between pregnant and non-pregnant women under the condition of COH were also investigated. Though serum E2 and serum SHBG were not different at the time of hCG injection (D0) between the pregnant and the non-pregnant group, the ratio of these two was different. In the non-pregnant group SHBG/Estradiol (S/E ratio) was significantly higher (p<0.05) than pregnant group at the time of hCG injection (D0). When daily changes of S/E ratio became plateau (same value as yesterday) that was the recommend timing of hCG injection. These results suggested that S/E ratio could be the good indicator for the timing of hCG injection during COH. If S/E ratio already started to increase at the time of hCG injection which represented the late timing of oocyte retrieval.
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