Abstract
目的 观察颅内感染患儿血清和脑脊液中C反应蛋白(CRP)及神经元特异性烯醇化酶(NSE)的含量变化及其意义.方法 以49例颅内感染患儿为研究对象,其中病毒性脑炎(病脑)21例,结核性脑膜炎(结脑)12例,化脓性脑膜炎(化脑)16例,分别采用免疫比浊法和放免法测定血清及脑脊液中CRP及NSE含量.结果 结脑组与化脑组血清与脑脊液中CRP含量差异无显著性(P＜0.05),而这两组均明显高于病脑组与对照组(P＜0.05),病脑组与对照组间差异也无显著性(P＜0.05).各组血清与脑脊液中NSE含量差异均有显著性(P＜0.05),依次为病脑组＞结脑组＞化脑组＞对照组.血清和脑脊液中CRP及NSE含量呈高度正相关(P＜0.05).结论 测定血清和脑脊液中CRP及NSE含量的变化有助于颅内感染的鉴别诊断及脑损害程度的判断.?＃
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