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Abstract
The collagen concentration and the total amount of collagen per tissue were determined in the uterus, skin and femurs of intact female rats and in the skin and femurs of intact male rats which had received specific quantities of 17β-estradiol benzoate for 14 days (1.8, 3.6 and 14 μg/100 g body wt daily and 50 and 100 μg/ 100 g body wt every 2nd day) and in similar untreated male and female animals. In the estradiol benzoate-treated rats, the collagen from the 3 tissues showed contrasting changes. Although the mg of collagen/uterus of the rats treated with 1.8, 3.6 and 14 μg of estradiol benzoate/100 g body wt daily were increased significantly (p <0.01, 0.01, 0.05), the per cent collagen in the dry fat-free uterus was decreased in each group of steroid-treated animals (decrease significant at p<0.05 for 1.8 μg/100 g body wt daily and p <0.01 for other dosages). A significant decrease (p <0.05, 0.01, 0.05, 0.05) in g of collagen/total skin was observed with female rats at estradiol benzoate dosages of 1.8 ...
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