Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study

Abstract

Background: Hepatitis A is a self-limited liver disease which can produce a significant cause of morbidity in parts of the world in pediatric population with low socioeconomic background. Hepatitis A can cause significant changes in liver functions changing its parameters. Aims and Objectives: The aim and objective of the study are to determine the biochemical changes in viral hepatitis A in tribal pediatric patients at the time of admission. Materials and Methods: This cross-sectional observational study was conducted in Deben Mahata Government Medical College and Hospital, Purulia, on confirmed newly diagnosed 100 hepatitis A tribal patients over a period of 12 months. Serum total and direct bilirubin, ALT, AST, alkaline phosphatase, total protein, and albumin were measured and data obtained were analyzed using appropriate statistical method. Results: Data collected from total hepatitis A patients were analyzed. Overall, 53% were male. 71% patients out of 100 presented with serum direct bilirubin level between 0.5 and 2.0 mg/dL and only 4 had more than 4.0 mg/dL. More than 5-fold rise in ALT and AST were seen in 75% and 82% cases, respectively. More than 1000U/L of ALT and AST were seen in 3 cases (3%) and 2 cases (2%), respectively. Among study population, alkaline phosphatase was elevated in 24% cases and 14% cases had hypoproteinemia. Nine cases admitted with raised blood urea level and one case with raised creatinine level. Conclusion: Hepatitis A produces alteration of the parameters of liver function.