CHANGES IN VENOUS TONE AND PERIPHERAL BLOOD CLOTTING PARAMETERSAFTER LAPAROSCOPIC LUMBAR SYMPATHECTOMY IN THE EXPERIMENT

Abstract

Objective: to develop the technique of laparoscopic lumbar sympathectomy in experiments on laboratory animals, to evaluate changes in venous tone and peripheral blood clotting after experimental surgical interventions using ultrasound and laboratory methods. Materials and methods. The study was performed on 9 rabbits. It included four stages united by a common target: an anatomical study of the sympathetic, preoperative study of venous tone and function of the blood clotting system, experimental surgery: in animals of the control group - diagnostic laparoscopy, in animals of the experimental group-laparoscopic right-sided lumbar sympathectomy, postoperative study of venous tone and function of the blood clotting system. Results of the study. According to blood coagulology tests these results have been obtained in the control animal: in the postoperative period comparing with the preoperative period, the increase in prothrombin time was 22.5% of the initial value, thrombin time was 14.6%, activated partial thromboplastin time was 3.1%, and fibrinogen was 52.3%. In the experimental group, the average increase was, respectively: prothrombin time 24.2%, thrombin time 26.1%, activated partial thromboplastin time 25.3%, fibrinogen 55.5%. According to the analysis of echograms in animals of the experimental group the index of orthostatic dilatation increased on the side of surgery, while on the contralateral (intact) side it decreased. The tone of the femoral vein on the animal's limb, on the side of which sympathetic ganglia have been coagulated, was reduced. Conclusion. Lumbar sympathectomy causes a decrease of the tone of the pelvic limb veins which was revealed according to the performed orthostatic test and increase in the time of peripheral blood clotting in the postoperative period (2 tables, bib liography: 7 refs).