Abstract
A complete understanding of excitation /contraction coupling in cardiac muscle requires knowledge of the sequence of structural changes in the myofilaments in response to the release of calcium from internal stores. We used isolated, membrane intact, electrically stimulated, cardiac trabeculae to obtain improved 2-dimensional X-ray patterns under three conditions: 1) diastolic conditions (no Calcium), 2) at peak calcium response but with 5 mM EGTA to inhibit calcium response and 3) at peak calcium response but where force was inhibited using the myosin ATPase inhibitor Blebbistatin which prevents strong binding of myosin heads to the thin filament.
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