Abstract
The aim of the research. The influence of hydrogen sulphide donor on some structural characteristics of platelets and leukocytes in patients with arterial hypertension was studied. Materials and methods. The survey involved patients (men) with hypertension aged 30–60 years, who were divided into 2 age groups: 30–40 years and 40–60 years. Control groups (healthy men without signs of hypertension) were randomized by age. Electron microscopic and morphometric research methods were used in the investigation. Results. Electron microscopic and morphometric evaluation of the structure of these cells has shown that it undergoes significant changes depending on patient’s age. In the persons of the older age group, the cells contained a reduced number of dense δ-granules and increased – α-granules, which may indicate an impaired serotonin balance and increased susceptibility to thrombogenesis. The younger age group presented structural changes in platelets in a reversed order. Adding hydrogen sulphide donor at a dose of 400 mg per day (phytopreparation Full Spectrum Garlic – Swanson Health Products, USA) to the traditional therapy of arterial hypertension leads to positive changes in the ultrastructure of the studied cells aimed at restoring the balance of serotonin, reducing the tendency to thrombogenesis, increasing the energy capacity of the mitochondrial apparatus. Conclusion. The obtained results indicate that detected effects significantly depend on the patient’s age (younger people respond more intensively) and the duration of the use of hydrogen sulphide donor (longer use is accompanied by more pronounced positive changes).
Highlights
In the scientific literature of recent years, considerable attention has been paid to low molecular weight signalling molecules, which are generally referred to NO and CO2
The aim of the study was to investigate the effect of hydrogen sulphide donor on some of the structural characteristics of platelets and leukocytes in patients with arterial hypertension
We found significant differences in the structural organization of L and T in persons with hypertension in different age groups examined before the start of the standard treatment process
Summary
In the scientific literature of recent years, considerable attention has been paid to low molecular weight signalling molecules, which are generally referred to NO and CO2. It was found that H2S referred to them [1, 2]. It is believed that the main biological effects of H2S include the regulation of vascular tone, contractile activity of the myocardium, participation in long-term synaptic potentiation, pro- and anti-inflammatory reactions, regulation of insulin secretion, etc. Hydrogen sulphide has been shown to have antioxidant and anti-apoptotic properties [5]. The cardiovascular system is subject to H2S action. Like NO and CO, it relaxes the smooth muscles of the blood vessels, reduces blood pressure and heart rate [6, 7]. There is a direct correlation between the severity of the disease and the level of hydrogen sulphide in blood: the more pronounced hypertension – the greater the hydrogen sulphide deficiency [8]
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