Changes in the lipid balance in the gastric mucosa in rats under acute stress

Abstract

BACKGROUND: Stress gastric ulcers are a type of peptic ulcer that develops in response to severe physiological or psychological stress. The causes of stress ulcers in the gaster have not yet been fully studied. AIM: To evaluate the composition of lipids in the gastric mucosa in rats under acute stress. MATERIALS AND METHODS: All rats included in the study (n=30) were divided into two groups. Group 1 (main group, n=20) included animals that had a model of stress gastric ulcer created by stimulation with electrical impulses for 12 hours. Group 2 (control group, n=10) included animals that had not been manipulated. At the end of the experiment, the effective and total concentration in blood serum of all animals was determined, followed by the calculation of the albumin binding reserve, and the plasma toxicity index. We also visually assessed the degree of damage to the gastric mucosa and determined the composition of lipids. RESULTS: Our study showed that a stressful situation led to the development of endogenous intoxication of group 1 animals. A decrease in the level of phosphatidylcholine by 16.3% and phosphatidylserine by 18.6% in stressed rats demonstrates the destruction of the cell membrane against the background of apoptosis, which macroscopically manifests itself in the form of spot hemorrhages, erosions and ulcers in the gastric mucosa. An increase in monoacylglycerol by 34.4% and diacylglycerol by 53.4% in group 1 animals indicates an increase in membrane permeability and induction of regenerative processes. CONCLUSIONS: In a stressful situation, against the background of a decrease in the total and effective concentration of albumin, endogenous intoxication develops, which contributes to a violation of the lipid balance and damage to cell membranes and the development of acute damage to the gastric mucosa.