Abstract
A low molecular weight melanoprotein from Ommastrephes bartrami LESUEL (Fr. SM II) has been reported to have a gastric secretion inhibitory activity in rats. The effect of Fr. SM II on the gastric mucosal defensive capability was studied in this investigation. It was demonstrated that Fr. SM II : i) counteracted ulceration induced by phenylbutazone and aspirin; ii) increased the contents of gastric glycoproteins in the ulcerated stomach; iii) lowered the activities of glycoprotein-degrading enzymes; and iv) increased the 35SO2-4 uptake into the gastric mucosa in intact rats concomitantly with an increase of glycoprotein content. It is suggested that the anti-ulcerogenic activity of Fr. SM II is based on its glycoprotein-increasing activity in the gastric mucosa.
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