Abstract
The purpose of the study was TO analyze the fetoplacental complex hormone levels and changes in their dynamics in pregnant women with miscarriage and the impact of these features on the subsequent course of pregnancy. Hormone levels were determined at different stages of gestation in 50 healthy women with a physiological course of pregnancy (control group) and 50 pregnant women with a history of miscarriage (main group). The women of the main group had a significantly slower rate of increase in hormones and a lag in quantitative indicators than the control group. The estradiol level indicators were 4.1 times (76.0%) and 2.89 times (65.5%) lower in women with miscarriage in the embryonic and late fetal period, respectively, compared to healthy women. Indicators of the level of placental lactogen and chorionic gonadotropin in the embryonic period in women with miscarriage were lower by 39.1% and 50.9%, respectively, compared to healthy women. In the late fetal period, the level of these hormones was lower by 72.9% and 35.4%, respectively. In the embryonic and late fetal periods, progesterone levels were lower by 67.4% and 68.4%, respectively, compared to the control group. The data obtained are evidence of a pronounced hormonal abnormality of the placenta, and hence a marker of fetoplacental dysfunction, which on the background of miscarriage develops at the early stages and continues to progress with the course of pregnancy.
Highlights
Pregnancy disorders are quite common, accounting for 10–20% of the total number of pregnancies [1]
Analyzing the hormonal status of pregnant women in the main group, we found that the content of chorionic gonadotropin and placental lactogen in the blood plasma of pregnant women throughout the gestation period was significantly lower compared to the control group
Women with miscarriage had a much slower increase in hormone levels and a lag in quantitative indicators compared with healthy women
Summary
Pregnancy disorders are quite common, accounting for 10–20% of the total number of pregnancies [1]. The average prevalence of women with a single miscarriage in her medical history is 11% [2, 3]. This significantly affects the physical and psychological well-being of women. The function of the fetoplacental complex (FPC), which synthesizes several hormones and proteins, plays an essential role in ensuring the normal course of pregnancy [8]. Disorders of the hormonal function of the fetoplacental complex, which is assessed by changes in the level of hormones produced by it, underlie the pathogenesis of various complications of pregnancy, including miscarriage [9, 10]
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