Abstract
The dynamics of redistribution of the isozyme spectrum of lactate and malate dehydrogenases in rat embryonic fibroblasts (REF) in contact with type 12 human adenovirus was studied and compared with the dynamics of changes in the fine structure of the mitochondria of the same cell models. The action of the oncogenic virus was shown to produce changes in the isozyme spectra of lactate and malate dehydrogenases in both the nucleus and cytoplasm. These disturbances began after the first days of interaction between the REF culture and the oncogenic virus and were not connected with proliferative growth of the cell culture, but were due to the action of the virus on the cell. Comparison of the kinetics of changes in the enzymes studied with the results of quantitative analysis of the ultrastructure of the mitochondrial apparatus showed that the biochemical changes arise much sooner, virtually at the moment of infection.
Published Version
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